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 Posted: Mon Sep 22, 2008 3:26 pm
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http://news.nationalgeographic.com/news/2004/03/0310_040310_blackdeath.html
Bubonic Plague Traced to Ancient Egypt
Cameron Walker
for National Geographic News
March 10, 2004
The bubonic plague, or Black Death, may have originated in ancient Egypt, according to a new study.
"This is the first time the plague's origins in Egypt have been backed up by archaeological evidence," said Eva Panagiotakopulu, who made the discovery. Panagiotakopulu is an archaeologist and fossil-insect expert at the University of Sheffield, England.
While most researchers consider central Asia as the birthplace of the deadly epidemic, the new study—published recently in the Journal of Biogeography—suggests an alternate starting point.
"It's usually thought that the plague entered from the East," said B. Joseph Hinnebusch, a microbiologist at Rocky Mountain Laboratories in Hamilton, Montana. The new study suggests that North Africa could also be the source of the epidemic, he said.
The bacteria-caused plague is more than a grim historical footnote today. The African island of Madagascar experienced outbreaks in the late 1990s, and some worry about the plague's potential use as an agent of bioterrorism.
Information about past epidemics could help scientists predict where new outbreaks would occur and better understand how the disease spreads, Hinnebusch said.
Plague in Europe
The most famous plague outbreak swept through Europe in the 1300s. Dubbed the Black Death, the disease killed more than 25 million people—one-fourth of the continent's population. The nursery rhyme "Ring Around the Rosy" is traced to the plague's rose-colored lesions and deadly spread.
Earlier outbreaks also decimated Europe. The Justinian Plague claimed as many as a hundred million lives in the Byzantine Empire during the sixth century A.D.
The bacterium that causes bubonic plague, Yersinia pestis, lives inside the gut of its main carrier, the flea. The plague likely spread to Europe on the backs of shipboard black rats that carried plague-infested fleas.
"It's the plague's unholy trinity," said Michael Antolin, a biologist at Colorado State University in Fort Collins, who studies bubonic plague in black-tailed prairie dogs.
Inside the flea, bacteria multiply and block off the flea's throat-like area. The flea gets increasingly hungry. When it bites—whether rat or human—it spits some bacteria out into the bite wound.
People can contract several forms of the plague. The main form, bubonic, often starts out with fever, chills, and enlarged lymph nodes. But if the bacteria make their way into the lungs, a deadlier form, called pneumonic plague, can be spread from person to person. Pneumonic plague occurs in about 5 percent of those infected with bubonic plague.
Several researchers have suggested that Europe's Black Death spread too fast and killed too many to be attributed to bubonic plague. But plague experts Hinnebusch and Antolin said that the pneumonic plague form could have been responsible for the quick-spreading epidemic.
"If you inhale it, you're pretty much dead," Antolin said.
Pharaohs' Plague
Panagiotakopulu came upon clues to the plague's presence in ancient Egypt by accident. She had been looking at fossil insect remains to learn about daily life more than 3,000 years ago.
"People lived close to their domestic animals and to the pests that infected their household," Panagiotakopulu said. "I just started looking at what diseases people might have, what diseases their pigs might have, and what diseases might have been passed from other animals to humans."
The researcher used a fine sieve to strain out remains of insects and small mammals from several sites. Panagiotakopulu, who is conducting similar work on Viking ruins in Greenland, said that looking at insects is a key way to reconstruct the past. "I can learn about how people lived by looking in their homes and at what was living with and on them," she said.
In Egypt Panagiotakopulu combed the workers'-village site in Amarna, where the builders of the tombs of Egyptian kings Tutankhamun and Akhenaton lived. There, the researcher unearthed cat and human fleas—known to be plague carriers in some cases—in and around the workers' homes. That find spurred Panagiotakopulu to believe that the bubonic plague's fleaborne bacteria could also have been lurking in the area, so she went in search of other clues.
Previous excavations along the Nile Delta had turned up Nile rats, an endemic species, dating to the 16th and 17th century B.C. The plague's main carrier flea is thought to be native to the Nile Valley and is known to be a Nile rat parasite.
According to Panagiotakopulu, the Nile provided an ideal spot for rats to carry the plague into urban communities. Around 3500 B.C., people began to build cities next to the Nile. During floods, the habitat of the Nile rat was disturbed, sending the rodent—and its flea and bacterial hitchhikers—into the human domain.
Egyptian writings from a similar time period point to an epidemic disease with symptoms similar to the plague. A 1500 B.C. medical text known as the Ebers Papyrus identifies a disease that "has produced a bubo, and the pus has petrified, the disease has hit."
It's possible that trade spread the disease to black rats, which then carried the bacteria to other sites of plague epidemics. Panagiotakopulu suspects that black rats, endemic to India, arrived in Egypt with sea trade. In Egypt the rats picked up plague-carrying fleas and were later born on ships that sailed across the Mediterranean to southern Europe.
Present-day Plague
"Most people think of the plague as a historical disease," said Hinnebusch, who conducts plague research for the U.S. National Institute of Allergy and Infectious Diseases. "But it's still out there, and it's still an international public health issue."
During the last ten years bubonic plague reappeared in Madagascar, which now has between 500 and 2,000 new cases each year.
According to the U.S. Centers for Disease Control and Prevention, the World Health Organization tallies as many as 3,000 plague cases each year around the world. Research interest in bubonic plague has been growing as, like anthrax, it could be used as a deadly bioterrorism agent (especially in pneumonic form).
While antibodies can be extremely effective against early stages of the plague, scientists are trying to learn more about how it works to be able to predict outbreaks and counteract the bacterium's scrambling of the immune system.
"There are so many unanswered questions about the plague," Hinnebusch said.
The plague will sleep for decades, even centuries, reemerge, and then seem to vanish again.
Panagiotakopulu said she wants to continue to track the evidence for the plague in Egypt and elsewhere to expand understanding of the still-mysterious epidemic.
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Posted: Mon Sep 22, 2008 3:34 pm
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Posted: Tue Sep 23, 2008 2:05 pm
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Yeah, I agree with Weben. And I'd like to stick up for this little guy being made out as the hellbringer of all death and pain and suffering. Isn't he cute? x3
The presence of rats and fleas at the same time does not automatically signify "zOMG bubonik plegues!!!11". After all, rodentiae have the most global spread of any mammal that doesn't have the name Homo sapiens, and fleas come with anything with hair or fur. I like the part where it says "the researcher unearthed cat and human fleas...in and around the worker's homes." Well, yeah, cats were pest control and walking deities. So naturally their hangers-on would be there as well. That proves nothing.
Also, another reason that the plague spread so fast and so widely in Europe was the lack of adequate sewage disposal at the time. Diseases breed like...well, like rats in such conditions. Pan makes no mention of such findings, if she found them at all. It would be interesting to observe sewage facilities in the places she's studied and how they relate to her observations on the plague in ancient Egypt.
Bubonic plague is also not the only plague the ancient Egyptians had to deal with (gasp!). The article makes it seem that other plague-causing diseases, notably smallpox, had not existed back then, which is simply not the case. Smallpox wasn't fully eradicated until 1979. And it has a similar attack pattern to the bubonic plague - which may or may not have been differentiated from bubonic plague in the Ebers Papyrus mentioned.
It's entirely possible that the bubonic plague was alive and well in ancient Egypt. But I'm not going to make a call based on Pan's article alone.
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Posted: Fri Sep 26, 2008 3:24 pm
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Posted: Mon Sep 29, 2008 10:57 am
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Reply
