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Who knows something might happen to Locke since he as well was exposed to High Radiation. Oh the Questions.
The problem wasn't caused by radiation, it's caused by traveling to and from the island incorrectly, exposure to radiation just makes it worse.
Example: Daniel told the pilot to stay on a bearing of 305 degrees North. Ben told Michael to follow a bearing of 325 degrees north. Because the pilot and Sayid weren't exposed to radiation, the difference didn't alter them, but since Desmond was, it made him go loopy.
I doubt Locke would leave the island alive (though I wouldn't be surprised if they made him the last of the 6 just to ******** with us
stressed ) so he probably won't have that problem...